Manchester United must now prepare to face Liverpool on Sunday without goalkeeper David de Gea and midfielder Paul Pogba.
Pogba has been ruled out with the ankle injury that has forced him to miss five of United’s past seven matches.
And manager Ole Gunnar Solskjaer is not expecting De Gea to be fit after the United goalkeeper suffered a groin injury on international duty with Spain on Tuesday night.
De Gea was due to return to Manchester on Wednesday night and will undergo a thorough assessment on Thursday to determine the full extent of the problem.
The Spaniard had felt an abductor muscle tighten during his country’s 1-1 draw against Sweden in Stockholm but agreed to play on only to pull up after attempting a clearance in a fresh setback for Solskjaer ahead of a crucial game.
United – who expect to welcome back Anthony Martial and Victor Lindelof after injury and Aaron Wan-Bissaka following illness – are currently 12th, two points off the relegation zone.